Citation:
Nadine Peart Akindele, Kouo, Theodore , Karaba, Andrew H, Gordon, Oren , Fenstermacher, Katherine ZJ, Beaudry, Jeanette , Rubens, Jessica H, Atik, Christine C, Zhou, Weiqiang , Ji, Hongkai , Tao, Xueting , Vaidya, Dhananjay , Mostafa, Heba , Caturegli, Patrizio , Blair, Paul W, Sauer, Lauren , Cox, Andrea L, and Persaud, Deborah . 2021.
“Distinct Cytokine And Chemokine Dysregulation In Hospitalized Children With Acute Covid-19 And Multisystem Inflammatory Syndrome With Similar Levels Of Nasopharyngeal Sars-Cov-2 Shedding”. The Journal Of Infectious Diseases, Pp. jiab285. doi:10.1093/infdis/jiab285.
Abstract:
{Background Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe clinical phenotype of SARS-CoV-2 infection that remains poorly understood. Methods Hospitalized children <18 years of age with suspected COVID-19 (N=53) were recruited into a prospective cohort study; 32 had confirmed COVID-19, with 16 meeting the U.S. Centers for Disease Control criteria for MIS-C. Differences in nasopharyngeal viral RNA levels, SARS-CoV-2 seropositivity, and cytokine/chemokine profiles were examined, including after adjustments for age and sex. Results The median ages for those with and without MIS-C were 8.7 years (IQR 5.5-13.9) and 2.2 years (IQR 1.1-10.5), respectively, (p=0.18) and nasopharyngeal levels of SARS-CoV-2 RNA did not differ significantly between the two groups (median 63,848.25 copies/mL versus 307.1 copies/mL
