@article {peart_akindele_distinct_2021,
	title = {Distinct Cytokine and Chemokine Dysregulation in Hospitalized Children with Acute COVID-19 and Multisystem Inflammatory Syndrome with Similar Levels of Nasopharyngeal SARS-CoV-2 Shedding},
	journal = {The Journal of Infectious Diseases},
	year = {2021},
	month = {may},
	pages = {jiab285},
	abstract = {{Background Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe clinical phenotype of SARS-CoV-2 infection that remains poorly understood. Methods Hospitalized children <18 years of age with suspected COVID-19 (N=53) were recruited into a prospective cohort study; 32 had confirmed COVID-19, with 16 meeting the U.S. Centers for Disease Control criteria for MIS-C. Differences in nasopharyngeal viral RNA levels, SARS-CoV-2 seropositivity, and cytokine/chemokine profiles were examined, including after adjustments for age and sex. Results The median ages for those with and without MIS-C were 8.7 years (IQR 5.5-13.9) and 2.2 years (IQR 1.1-10.5), respectively, (p=0.18) and nasopharyngeal levels of SARS-CoV-2 RNA did not differ significantly between the two groups (median 63,848.25 copies/mL versus 307.1 copies/mL},
	issn = {0022-1899},
	doi = {10.1093/infdis/jiab285},
	url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241418/},
	author = {Peart Akindele, Nadine and Kouo, Theodore and Karaba, Andrew H and Gordon, Oren and Fenstermacher, Katherine Z J and Beaudry, Jeanette and Rubens, Jessica H and Atik, Christine C and Zhou, Weiqiang and Ji, Hongkai and Tao, Xueting and Vaidya, Dhananjay and Mostafa, Heba and Caturegli, Patrizio and Blair, Paul W and Sauer, Lauren and Cox, Andrea L and Persaud, Deborah}
}
